Journal article icon

Journal article

Variation and genetic control of gene expression in primary immunocytes across inbred mouse strains.

Abstract:

To determine the breadth and underpinning of changes in immunocyte gene expression due to genetic variation in mice, we performed, as part of the Immunological Genome Project, gene expression profiling for CD4(+) T cells and neutrophils purified from 39 inbred strains of the Mouse Phenome Database. Considering both cell types, a large number of transcripts showed significant variation across the inbred strains, with 22% of the transcriptome varying by 2-fold or more. These included 119 loci w...

Expand abstract

Actions


Access Document


Publisher copy:
10.4049/jimmunol.1401280

Authors


Expand authors...
Publisher:
American Association of Immunologists
Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
193
Issue:
9
Pages:
4485-4496
Publication date:
2014-11-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:40e5496a-39bd-41b1-b5b6-e4b89b6fe784
Source identifiers:
485472
Local pid:
pubs:485472
Language:
English
Keywords:

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP