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Embryos with morphokinetic abnormalities may develop into euploid blastocysts

Abstract:

Irregular cleavage divisions are expected to produce chromosomally deviant embryos. We investigated whether embryos from irregular cleavages could develop into euploid blastocysts, and, if so, whether any evidence existed of a self-correction mechanism of the embryo. We also investigated the role of different dynamic aspects of morula compaction in this process. A total of 791 embryos from 141 patients undergoing pre-implantation genetic screening were retrospectively analysed using a time-la...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.rbmo.2016.11.008

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Obstetrics & Gynaecology
Role:
Author
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Publisher:
Elsevier Publisher's website
Journal:
Reproductive Biomedicine Online Journal website
Volume:
34
Issue:
2
Pages:
137-146
Publication date:
2016-11-24
Acceptance date:
2016-11-15
DOI:
EISSN:
1472-6491
ISSN:
1472-6483
Pubs id:
pubs:666264
URN:
uri:40e2471a-2b8d-4f9a-a381-395bfd9431a5
UUID:
uuid:40e2471a-2b8d-4f9a-a381-395bfd9431a5
Local pid:
pubs:666264

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