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A study of genomic instability in early preneoplastic colonic lesions

Abstract:

It is difficult to explain the differential rates of progression of premalignant colonic lesions and differences in behaviour of morphologically similar lesions. Heterogeneity for microsatellite instability (MSI) and promoter methylation in driving these phenomena forward may explain this; however, no previous analysis has examined this in detail at the gland level, the smallest unit of colorectal premalignant lesions. We aimed to carry out an analysis of gland level genomic instability for M...

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Publisher copy:
10.1038/onc.2012.584

Authors


Domingo, E More by this author
Abulafi, M More by this author
Hodgson, SV More by this author
Tomlinson, IPM More by this author
Journal:
Oncogene
Volume:
32
Issue:
46
Pages:
5333-5337
Publication date:
2013-11-14
DOI:
EISSN:
1476-5594
ISSN:
0950-9232
URN:
uuid:40db71a7-7ec4-4757-b6c7-0e779b922286
Source identifiers:
440929
Local pid:
pubs:440929

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