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Journal article

Compartmentalized phosphodiesterase-2 activity blunts beta-adrenergic cardiac inotropy via an NO/cGMP-dependent pathway.

Abstract:

beta-Adrenergic signaling via cAMP generation and PKA activation mediates the positive inotropic effect of catecholamines on heart cells. Given the large diversity of protein kinase A targets within cardiac cells, a precisely regulated and confined activity of such signaling pathway is essential for specificity of response. Phosphodiesterases (PDEs) are the only route for degrading cAMP and are thus poised to regulate intracellular cAMP gradients. Their spatial confinement to discrete compart...

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Journal:
Circulation research
Volume:
98
Issue:
2
Pages:
226-234
Publication date:
2006-02-05
DOI:
EISSN:
1524-4571
ISSN:
0009-7330
URN:
uuid:40d25f2b-4281-4c89-a839-ef5ce9ab05d6
Source identifiers:
237177
Local pid:
pubs:237177

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