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The transcription factor Erg inhibits vascular inflammation by repressing NF-kappaB activation and proinflammatory gene expression in endothelial cells.

Abstract:

OBJECTIVE: To test whether ETS-related gene (Erg) inhibits tumor necrosis factor (TNF)-α-dependent endothelial activation and inflammation. METHODS AND RESULTS: Endothelial activation underlies many vascular diseases, including atherosclerosis. Endothelial activation by proinflammatory cytokines decreases expression of the ETS transcription factor Erg. By using human umbilical vein endothelial cells (HUVECs), we showed that Erg overexpression by adenovirus (AdErg) repressed basal and TNF-α-in...

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Publication status:
Published

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Publisher copy:
10.1161/atvbaha.110.216473

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Journal:
Arteriosclerosis, thrombosis, and vascular biology
Volume:
31
Issue:
1
Pages:
142-150
Publication date:
2011-01-05
DOI:
EISSN:
1524-4636
ISSN:
1079-5642
URN:
uuid:40c3df1f-06bf-4548-b157-25cd461f35e1
Source identifiers:
230218
Local pid:
pubs:230218

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