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Thesis

Use of patient-derived cellular models to investigate the mechanistic basis of circadian dysfunctions and chronomodulatory drugs in bipolar disorder

Abstract:

Bipolar disorder is a highly incapacitating neuropsychiatric disorder, where patients exhibit cycling episodes of mania and depression. In addition to these characteristics, sleep and circadian rhythm disruptions are frequently observed through changes in physiology and behaviour. Lithium treatment remains effective in inducing acute and long-term mood stabilisation, yet there is ambiguity as to how it exerts its therapeutic benefits. As lithium induces significant chronomodulatory effects...

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Supervisor
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Funding agency for:
Project
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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