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Acute cisplatin nephrotoxicity in the rat. Evidence for impaired entry of sodium into proximal tubule cells.

Abstract:

The earliest phase of cisplatin nephrotoxicity involves natriuresis due to impaired sodium reabsorption by the proximal tubule. To define the cell mechanism of this transport lesion, electron microprobe X-ray analysis was used to determine changes in the electrolyte composition of proximal tubule cells in kidneys taken from rats treated acutely with cisplatin (1 mg/100 g body weight). Compared to control animals injected with vehicle, cisplatin treated rats developed significant natriuresis, ...

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Publication status:
Published

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Publisher copy:
10.1007/bf00582130

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Institution:
University of Oxford
Department:
Oxford, MPLS, Materials
Role:
Author
Journal:
Pflugers Archiv : European journal of physiology
Volume:
414
Issue:
6
Pages:
647-650
Publication date:
1989-09-05
DOI:
EISSN:
1432-2013
ISSN:
0031-6768
URN:
uuid:40b26973-741c-494d-ac00-3d59c67749fe
Source identifiers:
17990
Local pid:
pubs:17990

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