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Mechanisms of allergen-specific desensitization.

Abstract:

BACKGROUND: Allergen-specific desensitization (SIT) is the most effective therapy for allergies. Although allergen-specific antibodies have an important role in the process, mechanisms of IgG-mediated inhibition of allergic reactions are not well defined. OBJECTIVE: We investigated mechanisms by which SIT-induced allergen-specific IgGs inhibit allergic reactions. METHODS: We generated mAbs that recognize 3 nonoverlapping epitopes of the major cat allergen Fel d 1. Each of the mAbs was produc...

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Publication status:
Published

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Publisher copy:
10.1016/j.jaci.2010.05.040

Authors


Uermösi, C More by this author
Beerli, RR More by this author
Manolova, V More by this author
Dietmeier, K More by this author
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Journal:
The Journal of allergy and clinical immunology
Volume:
126
Issue:
2
Pages:
375-383
Publication date:
2010-08-05
DOI:
EISSN:
1097-6825
ISSN:
0091-6749
URN:
uuid:40aad317-f3c0-463d-8716-df1b443c1eb7
Source identifiers:
422339
Local pid:
pubs:422339

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