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Delays in Post-Remission Chemotherapy for Philadelphia Chromosome Negative Acute Lymphoblastic Leukemia are Associated with Inferior Outcomes in Patients who Undergo Allogeneic Transplant: An Analysis from ECOG 2993/MRC UK ALLXII.

Abstract:

Adults with acute lymphoblastic leukemia (ALL) have a poorer prognosis than children due to a high risk of relapse. One explanation may be variable adherence to dose-intense chemotherapy. However, little is known about risk factors for delays in therapy and their impact on survival. We conducted an analysis of ECOG 2993/UKALLXII trial to study delays in post-remission chemotherapy in adults with newly-diagnosed ALL. Logistic regression was used to identify risk factors for a very long delay (...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/ajh.24497

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Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
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Grant:
T32 CA009679/NCI
P30 CA008748/NCI
U10 CA013650/NCI
U10 CA014958/NCI
U10 CA017145/NCI
U10 CA021115/NCI
U10 CA066636/NCI
U10 CA180790/NCI
U10 CA180791/NCI
U10 CA180820/NCI
U10 CA180853/NCI
UG1 CA189859/NCI
Publisher:
Wiley Publisher's website
Journal:
American Journal of Hematology Journal website
Volume:
91
Issue:
11
Pages:
1107–1112
Publication date:
2016-08-22
Acceptance date:
2016-07-26
DOI:
ISSN:
1096-8652 and 0361-8609
Pmid:
27468137
Source identifiers:
636566
Language:
English
Keywords:
Pubs id:
pubs:636566
UUID:
uuid:40a955af-94e4-41f4-95d7-620b01351073
Local pid:
pubs:636566
Deposit date:
2016-10-18

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