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Cooling inhibits exocytosis in single mouse pancreatic B-cells by suppression of granule mobilization.

Abstract:

1. The mechanisms by which cooling inhibits insulin secretion were investigated by capacitance measurements of exocytosis in single mouse pancreatic B-cells maintained in short-term tissue culture. 2. A reduction of the bath temperature from 34 to 24 degrees C produced a gradual inhibition of exocytosis. Inhibition of exocytosis was use dependent rather than time dependent. The steady-state inhibition amounted to 90%, which was paralleled by a 30% reduction of the peak Ca2+ current. 3. The Q1...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
Journal:
Journal of physiology
Volume:
494 ( Pt 1)
Issue:
1
Pages:
41-52
Publication date:
1996-07-01
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
Source identifiers:
30955
Language:
English
Keywords:
Pubs id:
pubs:30955
UUID:
uuid:40a4b75e-6817-49e2-bd4c-246415598008
Local pid:
pubs:30955
Deposit date:
2012-12-19

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