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ILDR2 Is a novel B7-like protein that negatively regulates T cell responses

Abstract:

The B7-like protein family members play critical immunomodulatory roles and constitute attractive targets for the development of novel therapies for human diseases. We identified Ig-like domain–containing receptor (ILDR)2 as a novel B7-like protein with robust T cell inhibitory activity, expressed in immune cells and in immune-privileged and inflamed tissues. A fusion protein, consisting of ILDR2 extracellular domain with an Fc fragment, that binds to a putative counterpart on activated T cel...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.4049/jimmunol.1700325

Authors


Toporik, A More by this author
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ORCID:
0000-0002-5818-8515
Cojocaru, G More by this author
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Publisher:
American Association of Immunologists Publisher's website
Journal:
Journal of Immunology Journal website
Volume:
200
Issue:
6
Pages:
2025-2037
Publication date:
2018-03-15
Acceptance date:
2018-01-03
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Pubs id:
pubs:826445
URN:
uri:4094a2d4-5aee-4643-b279-ae4d17065289
UUID:
uuid:4094a2d4-5aee-4643-b279-ae4d17065289
Local pid:
pubs:826445
Language:
English

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