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Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity

Abstract:

Thousands of genetic variants have been identified, which contribute to the development of complex diseases, but determining how to elucidate their biological consequences for translation into clinical benefit is challenging. Conflicting evidence regarding the functional impact of genetic variants in the tyrosine kinase 2 (TYK2) gene, which is differentially associated with common autoimmune diseases, currently obscures the potential of TYK2 as a therapeutic target. We aimed to resolve this c...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1126/scitranslmed.aag1974

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Department:
Oxford, MSD, Clinical Neurosciences
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Author
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Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
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Department:
Oxford, MSD, Clinical Neurosciences
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Author
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Department:
Oxford, MSD, Clinical Neurosciences
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Author
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Department:
Oxford, MSD, RDM, Weatherall Insti. of Molecular Medicine
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Grant:
100308/Z/12/Z; 106130/Z/14/Z; 100956/Z/13/Z
Medical Research Council More from this funder
Rosetrees Trust More from this funder
Alan and Babette Sainsbury Charitable Fund More from this funder
Oak Foundation More from this funder
Publisher:
American Association for the Advancement of Science Publisher's website
Journal:
Science Translational Medicine Journal website
Volume:
8
Issue:
363
Chapter number:
363ra149
Publication date:
2016-11-02
Acceptance date:
2016-09-19
DOI:
ISSN:
1946-6234 and 1946-6242
Pubs id:
pubs:656757
URN:
uri:4094051d-4bfd-4a71-bbaa-0e87c9cf03f9
UUID:
uuid:4094051d-4bfd-4a71-bbaa-0e87c9cf03f9
Local pid:
pubs:656757
Paper number:
363
Language:
English
Keywords:

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