- Abstract:
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Xylose isomerase (XI) is an industrially important metalloprotein studied for decades. Its reaction mechanism has been postulated to involve movement of the catalytic metal cofactor to several different conformations. Here, a dose-dependent approach was used to investigate the radiation damage effects on XI and their potential influence on the reaction mechanism interpreted from the X-ray derived structures. Radiation damage is still one of the major challenges for X-ray diffraction experimen...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted Manuscript
- Files:
-
-
(pdf, 2.8MB)
-
- Publisher copy:
- 10.1107/S1600577519005599
-
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- Publisher:
- International Union of Crystallography Publisher's website
- Journal:
- Journal of Synchrotron Radiation Journal website
- Volume:
- 26
- Issue:
- 4
- Pages:
- 931-944
- Publication date:
- 2019-06-24
- Acceptance date:
- 2019-04-23
- DOI:
- EISSN:
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1600-5775
- ISSN:
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0909-0495
- Pubs id:
-
pubs:995289
- URN:
-
uri:408c9beb-bf49-40a2-8afe-6ae343a69f07
- UUID:
-
uuid:408c9beb-bf49-40a2-8afe-6ae343a69f07
- Local pid:
- pubs:995289
- Copyright holder:
- International Union of Crystallography
- Copyright date:
- 2019
- Notes:
-
Copyright © 2019 International Union of Crystallography. This is the accepted manuscript version of the article. The final version is available online from International Union of Crystallography at: https://doi.org/10.1107/S1600577519005599
Journal article
Structural knowledge or X-ray damage? A case study on xylose isomerase illustrating both
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