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Structural knowledge or X-ray damage? A case study on xylose isomerase illustrating both

Abstract:

Xylose isomerase (XI) is an industrially important metalloprotein studied for decades. Its reaction mechanism has been postulated to involve movement of the catalytic metal cofactor to several different conformations. Here, a dose-dependent approach was used to investigate the radiation damage effects on XI and their potential influence on the reaction mechanism interpreted from the X-ray derived structures. Radiation damage is still one of the major challenges for X-ray diffraction experimen...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1107/S1600577519005599

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Oxford college:
Brasenose
Role:
Author
Publisher:
International Union of Crystallography Publisher's website
Journal:
Journal of Synchrotron Radiation Journal website
Volume:
26
Issue:
4
Pages:
931-944
Publication date:
2019-06-24
Acceptance date:
2019-04-23
DOI:
EISSN:
1600-5775
ISSN:
0909-0495
Pubs id:
pubs:995289
URN:
uri:408c9beb-bf49-40a2-8afe-6ae343a69f07
UUID:
uuid:408c9beb-bf49-40a2-8afe-6ae343a69f07
Local pid:
pubs:995289

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