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Electrohydrodynamic preparation of polymeric drug-carrier particles: mapping of the process.

Abstract:

Submicrometre size spheres prepared from biocompatible polymers are becoming increasingly popular in drug and gene delivery. This paper describes the preparation of polymeric spheres with a mean diameter of 0.4 μm with a polydispersivity index of 8%, using coaxial electrohydrodynamic atomization (CEHDA) microbubbling. An 18 wt.% solution of polymethylsilsesquioxane, a hydrophobic biocompatible polymer, was subjected to CEHDA microbubbling by passing air through the inner needle and polymer so...

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Authors


Enayati, M More by this author
Edirisinghe, M More by this author
Journal:
International journal of pharmaceutics
Volume:
404
Issue:
1-2
Pages:
110-115
Publication date:
2011-02-05
DOI:
EISSN:
1873-3476
ISSN:
0378-5173
URN:
uuid:408c307d-ac08-4a99-9e4d-e8bc703cc374
Source identifiers:
327749
Local pid:
pubs:327749

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