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Thesis

In vitro analysis of viral fusion and receptor binding with a focus on selected arthropod-borne viruses of the families Bunyaviridae and Togaviridae

Abstract:

Emerging arthropod-borne viruses, such as alphaviruses and bunyaviruses, represent a serious threat to human and animal health worldwide, and for most of them, vaccines and specific treatments are unavailable. Viral host cell entry can be divided into several entry checkpoints, and the most important checkpoints for low pH-dependent enveloped viruses, such as bunyaviruses and alphaviruses, include receptor binding at the cell surface and, followed by endocytosis, low pH dependent membrane ...

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Institution:
University of Oxford
Oxford college:
Green Templeton College
Department:
Medical Sciences Division

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Role:
Supervisor
Role:
Supervisor
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Funding agency for:
David Bitto
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:40875104-1eb6-47f6-b1e7-d26147c002a8
Local pid:
ora:9845

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