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Journal article

A point mutation in CD45 may be associated with an increased risk of HIV-1 infection.

Abstract:
The CD45 antigen is essential for normal antigen receptor-mediated signalling in lymphocytes, and different patterns of splicing of CD45 are associated with distinct functions in lymphocytes. Here we show that abnormal CD45 splicing caused by a C77G transversion in exon A of the gene encoding CD45 (PTPRC) is associated with increased susceptibility to HIV-1 infection.

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Authors


Tchilian, EZ More by this author
Wallace, DL More by this author
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Journal:
AIDS (London, England)
Volume:
15
Issue:
14
Pages:
1892-1894
Publication date:
2001-09-05
DOI:
EISSN:
1473-5571
ISSN:
0269-9370
URN:
uuid:4083540c-0be3-4b9a-9c2c-4b79f6d512d8
Source identifiers:
31954
Local pid:
pubs:31954

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