Journal article icon

Journal article

Chemical synthesis of the second messenger nicotinic acid adenine dinucleotide phosphate by total synthesis of nicotinamide adenine dinucleotide phosphate.

Abstract:
Signaling dinucleotides: The first single-isomer synthesis of nicotinamide adenine dinucleotide phosphate (NADP) is reported. Installation and maintenance of sensitive phosphate and pyridinium functionalities were key to success. Significantly, conversion of NADP into the important mammalian second messenger NAADP was achieved. The graph shows the biological evaluation of the activity of the release of Ca2+ ions, which confirms the identity of NAADP.
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1002/anie.200460054

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
Expand authors...
Journal:
Angewandte Chemie (International ed. in English)
Volume:
43
Issue:
35
Pages:
4637-4640
Publication date:
2004-09-01
DOI:
EISSN:
1521-3773
ISSN:
1433-7851
Source identifiers:
106502
Language:
English
Keywords:
Pubs id:
pubs:106502
UUID:
uuid:407b0a54-c741-4ec0-a40d-1ddb591b0209
Local pid:
pubs:106502
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP