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Chemical synthesis of the second messenger nicotinic acid adenine dinucleotide phosphate by total synthesis of nicotinamide adenine dinucleotide phosphate.

Abstract:
Signaling dinucleotides: The first single-isomer synthesis of nicotinamide adenine dinucleotide phosphate (NADP) is reported. Installation and maintenance of sensitive phosphate and pyridinium functionalities were key to success. Significantly, conversion of NADP into the important mammalian second messenger NAADP was achieved. The graph shows the biological evaluation of the activity of the release of Ca2+ ions, which confirms the identity of NAADP.
Publication status:
Published

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Publisher copy:
10.1002/anie.200460054

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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology, BHF Centre of Research Excellence
Role:
Author
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Journal:
Angewandte Chemie (International ed. in English)
Volume:
43
Issue:
35
Pages:
4637-4640
Publication date:
2004-09-05
DOI:
EISSN:
1521-3773
ISSN:
1433-7851
URN:
uuid:407b0a54-c741-4ec0-a40d-1ddb591b0209
Source identifiers:
106502
Local pid:
pubs:106502

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