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Genetic and functional analyses implicate the NUDT11, HNF1B, and SLC22A3 genes in prostate cancer pathogenesis.

Abstract:

One of the central goals of human genetics is to discover the genes and pathways driving human traits. To date, most of the common risk alleles discovered through genome-wide association studies (GWAS) map to nonprotein-coding regions. Because of our relatively poorer understanding of this part of the genome, the functional consequences of trait-associated variants pose a considerable challenge. To identify the genes through which risk loci act, we hypothesized that the risk variants are regu...

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Publisher copy:
10.1073/pnas.1200853109

Authors


Grisanzio, C More by this author
Awoyemi, BC More by this author
Pomerantz, MM More by this author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
109
Issue:
28
Pages:
11252-11257
Publication date:
2012-07-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:4079e0aa-7479-4073-895f-c3a156d64faf
Source identifiers:
414547
Local pid:
pubs:414547

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