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Acquisition of growth-inhibitory antibodies against blood-stage Plasmodium falciparum

Abstract:

Background: Antibodies that inhibit the growth of blood-stage Plasmodium falciparum may play an important role in acquired and vaccine-induced immunity in humans. However, the acquisition and activity of these antibodies is not well understood. Methods: We tested dialysed serum and purified immunoglobulins from Kenyan children and adults for inhibition of P. falciparum blood-stage growth in vitro using different parasite lines. Serum antibodies were measured by ELIS...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0003571

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Institution:
"The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia", "University of Melbourne, Australia"
Department:
Department of Medical Biology
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Institution:
"The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia"
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Institution:
"Kenya Medical Research Institute, CGMRC/Wellcome Trust Collaborative Program, Kilifi, Kenya"
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Institution:
"The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia"
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Institution:
"University of Melbourne, Australia"
Department:
Centre for Molecular,Environmental,Genetic and Analytic Epidemiology
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Funding agency for:
Thomas N. Williams
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Funding agency for:
Kevin Marsh
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
3
Issue:
10
Pages:
Article: e3571
Publication date:
2008-10-05
DOI:
EISSN:
1932-6203
URN:
uuid:40789924-d1cb-43d1-a9d0-e7eee322bbd3
Local pid:
ora:3077

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