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Risk of nontyphoidal Salmonella bacteraemia in African children is modified by STAT4

Abstract:

Nontyphoidal Salmonella (NTS) is a major cause of bacteraemia in Africa. The disease typically affects HIV-infected individuals and young children, causing substantial morbidity and mortality. Here we present a genome-wide association study (180 cases, 2677 controls) and replication analysis of NTS bacteraemia in Kenyan and Malawian children. We identify a locus in STAT4, rs13390936, associated with NTS bacteraemia. rs13390936 is a context-specific expression quantitative trait locus for STAT...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-017-02398-z

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Institution:
University of Oxford
Department:
NDM; Human Genetics Wt Centre
Oxford college:
St Anne's College
Role:
Author
ORCID:
0000-0003-2045-6788
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Institution:
University of Oxford
Department:
Oncology
Role:
Author
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Role:
Author
ORCID:
0000-0003-4281-8882
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Funding agency for:
Rautanen, A
Grant:
084716/Z/08/Z
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Funding agency for:
Rautanen, A
Grant:
084716/Z/08/Z
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Funding agency for:
Scott, JAG
Grant:
098532
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Funding agency for:
Hill, AVS
Grant:
294557
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Funding agency for:
Williams, TN
Grant:
091758
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Communications Journal website
Volume:
9
Issue:
1
Article number:
1014
Publication date:
2018-03-09
Acceptance date:
2017-11-27
DOI:
EISSN:
2041-1723
Pmid:
29523850
Language:
English
Pubs id:
pubs:830216
UUID:
uuid:406bf175-fb92-46ac-b252-b1a8b789fa06
Local pid:
pubs:830216
Deposit date:
2018-04-04

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