Uukuniemi Phlebovirus assembly and secretion leave a functional imprint on the virion glycome.
- Uukuniemi virus (UUKV) is a model system for investigating the genus Phlebovirus of the Bunyaviridae. We report the UUKV glycome, revealing differential processing of the Gn and Gc virion glycoproteins. Both glycoproteins display poly-N-acetyllactosamines, consistent with virion assembly in the medial Golgi apparatus, whereas oligomannose-type glycans required for DC-SIGN-dependent cellular attachment are predominant on Gc. Local virion structure and the route of viral egress from the cell leave a functional imprint on the phleboviral glycome.
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- Peer reviewed
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- Crispin et al
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- Copyright © 2014 Crispin et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 3.0 Unported license.
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