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Uukuniemi Phlebovirus assembly and secretion leave a functional imprint on the virion glycome.

Abstract:
Uukuniemi virus (UUKV) is a model system for investigating the genus Phlebovirus of the Bunyaviridae. We report the UUKV glycome, revealing differential processing of the Gn and Gc virion glycoproteins. Both glycoproteins display poly-N-acetyllactosamines, consistent with virion assembly in the medial Golgi apparatus, whereas oligomannose-type glycans required for DC-SIGN-dependent cellular attachment are predominant on Gc. Local virion structure and the route of viral egress from the cell leave a functional imprint on the phleboviral glycome.
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1128/jvi.01662-14

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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, NDM Experimental Medicine
Role:
Author
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International AIDS Vaccine Initiative More from this funder
Center for HIV/AIDS Vaccine Immunology More from this funder
Oriel College, Oxford More from this funder
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Publisher:
American Society of Microbiology Publisher's website
Journal:
Journal of Virology Journal website
Volume:
88
Issue:
17
Pages:
10244-10251
Publication date:
2014-09-05
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:4064b8e4-f641-4160-83de-6e8c898c29c3
Source identifiers:
470564
Local pid:
pubs:470564

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