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Conference item : Abstract

Differential regulation of FGFR3 controls FGFR1:FGFR3 balance in chondrocytes after cartilage injury

Abstract:

Release of FGF-2 from the pericelluar matrix of cartilage upon injury is an important early response of the tissue to injury. Even though FGF-2 knockout mice have substantially increased cartilage degradation in spontaneous and surgically induced models of osteoarthritis (OA), the in vitro literature is divided about the role of FGF-2 in articular cartilage. It is currently unclear whether FGF-2 is chondroprotective by promoting anabolic effects; or destructive through promotion of catabolic ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.joca.2016.01.269

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
Publisher:
Elsevier Publisher's website
Host title:
Osteoarthritis and Cartilage
Journal:
Osteoarthritis and Cartilage Journal website
Volume:
24
Issue:
S1
Pages:
S137
Publication date:
2016-03-20
DOI:
ISSN:
1063-4584
Keywords:
Subtype:
Abstract
Pubs id:
pubs:618831
UUID:
uuid:40606135-43c7-4f74-b900-8e6f5fc20f21
Local pid:
pubs:618831
Source identifiers:
618831
Deposit date:
2016-05-25

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