Journal article
Inositol pyrophosphates drive sodium-potassium pump degradation by relieving an autoinhibitory domain of PI3K p85α
- Abstract:
-
Sodium/potassium-transporting adenosine triphosphatase (Na+/K+-ATPase) is one of the most abundant cell membrane proteins and is essential for eukaryotes. Endogenous negative regulators have long been postulated to play an important role in regulating the activity and stability of Na+/K+-ATPase, but characterization of these regulators has been elusive. Mechanisms of regulating Na+/K+-ATPase homeostatic turnover are unknown. Here, we report that 5-diphosphoinositol 1,2,3,4,6-pentakisphosphate...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Funding
Bibliographic Details
- Publisher:
- American Association for the Advancement of Science Publisher's website
- Journal:
- Science Advances Journal website
- Volume:
- 6
- Issue:
- 44
- Article number:
- eabb8542
- Publication date:
- 2020-10-28
- Acceptance date:
- 2020-08-28
- DOI:
- EISSN:
-
2375-2548
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1128968
- Local pid:
- pubs:1128968
- Deposit date:
- 2020-09-03
Terms of use
- Copyright holder:
- Chin et al.
- Copyright date:
- 2020
- Rights statement:
- © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
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