Degradation of interleukin 1beta by matrix metalloproteinases.

Journal article

Matrix metalloproteinases (MMPs) and interleukin 1 (IL-1) are implicated in inflammation and tissue destruction, where IL-1 is a potent stimulator of connective tissue cells to produce the extracellular matrix-degrading MMPs. Here, we report that IL-1beta, but not IL-1alpha, is degraded by MMP-1 (interstitial collagenase), MMP-2 (gelatinase A), MMP-3 (stromelysin 1), and MMP-9 (gelatinase B). This degradation was effectively blocked by tissue inhibitor of metalloproteinases (TIMP)-1. When IL-...

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Authors: Ito, A; Mukaiyama, A; Itoh, Y; Nagase, H; Thogersen, I

• Journal: Journal of biological chemistry
• Volume: 271
• Issue: 25
• Pages: 14657-14660
• Publication date: 1996-06-01
• DOI: 10.1074/jbc.271.25.14657
• EISSN: 1083-351X
• ISSN: 0021-9258
• Language: English
• Keywords: Collagenases; Kinetics; Molecular Sequence Data; Fibrosarcoma; Inflammation; Sulfhydryl Reagents; Phenylmercuric Acetate; Substrate Specificity; Fibroblasts; Glycoproteins; Enzyme Activation; Cell Line; Matrix Metalloproteinase 3; Dinoprostone; Tissue Inhibitor of Metalloproteinases; Metalloendopeptidases; Humans; Amino Acid Sequence; Matrix Metalloproteinase 2; Matrix Metalloproteinase 1; Gelatinases; Interleukin-1; Matrix Metalloproteinase 9