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Degradation of interleukin 1beta by matrix metalloproteinases.

Abstract:

Matrix metalloproteinases (MMPs) and interleukin 1 (IL-1) are implicated in inflammation and tissue destruction, where IL-1 is a potent stimulator of connective tissue cells to produce the extracellular matrix-degrading MMPs. Here, we report that IL-1beta, but not IL-1alpha, is degraded by MMP-1 (interstitial collagenase), MMP-2 (gelatinase A), MMP-3 (stromelysin 1), and MMP-9 (gelatinase B). This degradation was effectively blocked by tissue inhibitor of metalloproteinases (TIMP)-1. When IL-...

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Publisher copy:
10.1074/jbc.271.25.14657

Authors


Mukaiyama, A More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Thogersen, IB More by this author
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Journal:
The Journal of biological chemistry
Volume:
271
Issue:
25
Pages:
14657-14660
Publication date:
1996-06-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:40586e86-7180-48c0-b4cd-b7a6d122b3fe
Source identifiers:
411405
Local pid:
pubs:411405

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