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Insulin-like growth factor (IGF) pathway targeting in cancer: role of the IGF axis and opportunities for future combination studies

Abstract:

Despite a strong preclinical rationale for targeting the insulin-like growth factor (IGF) axis in cancer, clinical studies of IGF-1 receptor (IGF-1R)-targeted monotherapies have been largely disappointing, and any potential success has been limited by the lack of validated predictive biomarkers for patient enrichment. A large body of preclinical evidence suggests that the key role of the IGF axis in cancer is in driving treatment resistance, via general proliferative/survival mechanisms, inte...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1007/s11523-017-0514-5

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
Publisher:
Springer International Publishing Publisher's website
Journal:
Targeted Oncology Journal website
Volume:
12
Issue:
5
Pages:
571–597
Publication date:
2017-08-16
Acceptance date:
2017-03-01
DOI:
EISSN:
1776-260X
ISSN:
1776-2596
Pmid:
28815409
Source identifiers:
724211
Language:
English
Pubs id:
pubs:724211
UUID:
uuid:405457d6-5e93-4e7a-8857-0774007e2fb0
Local pid:
pubs:724211
Deposit date:
2017-09-01

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