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Journal article

Loss of PFKFB4 induces cell death in mitotically arrested ovarian cancer cells

Abstract:

Taxanes represent some of the most commonly used chemotherapeutic agents for ovarian cancer treatment. However, they are only effective in approximately 40% of patients. Novel therapeutic strategies are required to potentiate their effect and improve patient outcome. A hallmark of many cancers is the constitutive activation of the PI3K/AKT pathway, which drives cell survival and metabolism. We discovered a striking decrease in AKT activity coupled with a significant reduction in glucose 6-pho...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.18632/oncotarget.14910

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Women's and Reproductive Health
Role:
Author
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Medical Research Council More from this funder
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Grant:
Oxford Biomedical Research Centre
Ovarian Cancer Action More from this funder
Publisher:
Impact Journals Publisher's website
Journal:
Oncotarget Journal website
Volume:
8
Issue:
11
Pages:
17960-17980
Publication date:
2017-01-31
Acceptance date:
2016-12-15
DOI:
ISSN:
1949-2553
Source identifiers:
679681
Language:
English
Keywords:
Pubs id:
pubs:679681
UUID:
uuid:4033bdb8-f282-4ddf-b0c9-b13122febebe
Local pid:
pubs:679681
Deposit date:
2017-08-03

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