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The ATP- and tolbutamide-sensitivity of the ATP-sensitive K-channel from human pancreatic B cells.

Abstract:

The ATP- and sulphonylurea-sensitivity of the ATP-sensitive K-channel was measured in human pancreatic B cells. In inside-out patches, half-maximal inhibition of channel activity was produced by 10 mumol/l ATP (with 2 mM Mg2+) and ATP-inhibition was partially antagonised by ADP. A significantly lower sensitivity to ATP was found in whole-cell recordings. Tolbutamide inhibited whole-cell ATP-sensitive K-currents half-maximally at 18 mumol/l; the sensitivity to tolbutamide was somewhat less in ...

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Publication status:
Published

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Publisher copy:
10.1007/bf00285333

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Gibson, JS More by this author
Publisher:
Springer-Verlag
Journal:
Diabetologia
Volume:
32
Issue:
8
Pages:
591-598
Publication date:
1989-08-05
DOI:
EISSN:
1432-0428
ISSN:
0012-186X
URN:
uuid:4024758f-a903-462c-83eb-6fd8189f4563
Source identifiers:
114297
Local pid:
pubs:114297

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