Mixing in large-scale vessels stirred with multiple radial or radial and axial up-pumping impellers: modelling and measurements

Journal article

Mixing phenomena are regarded as one of the major factors responsible for the failure to successfully scale up some bioprocesses. Such phenomena have been investigated within the framework of an EC project `Bioprocess Scale-up Strategy'. Mixing in bioreactors depends on energy input, impeller type, reactor configuration and impeller geometry. Here, two different reactors of volumes 12 and 30 m3 were used, and they were equipped with either multiple Rushton turbines or with a combination of a ...

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Authors: Vrabel, P; van der Lans, R; Luyben, K; Boon, L; Nienow, A

• Publication status: Published
• Publisher: Elsevier
• Journal: CHEMICAL ENGINEERING SCIENCE
• Volume: 55
• Issue: 23
• Pages: 5881-5896
• Publication date: 2000-12-01
• DOI: 10.1016/S0009-2509(00)00175-5
• ISSN: 0009-2509
• Language: English
• Keywords: up-pumping and radial stirrers; scale-up; multiple impellers; stirred bioreactor; modelling