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Human ischemic cardiomyopathy shows cardiac nos1 translocation and its increased levels are related to left ventricular performance

Abstract:

The role of nitric oxide synthase 1 (NOS1) as a major modulator of cardiac function has been extensively studied in experimental models; however, its role in human ischemic cardiomyopathy (ICM) has never been analysed. Thus, the objectives of this work are to study NOS1 and NOS-related counterparts involved in regulating physiological function of myocyte, to analyze NOS1 localisation, activity, dimerisation, and its relationship with systolic function in ICM. The study has been carried out on...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/srep24060

Authors


Roselló-Lletí, E More by this author
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Department:
Oxford, MSD, RDM, RDM Cardiovascular Medicine
Tarazón, E More by this author
Gil-Cayuela, C More by this author
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Scientific Reports Journal website
Volume:
6
Pages:
24060
Publication date:
2016-04-04
Acceptance date:
2016-03-18
DOI:
ISSN:
2045-2322
Pubs id:
pubs:614721
URN:
uri:401826a9-992c-4cfd-bdd3-d63837e9321f
UUID:
uuid:401826a9-992c-4cfd-bdd3-d63837e9321f
Local pid:
pubs:614721
Language:
English
Keywords:

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