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Delayed disease progression in HIV-2: the importance of TRIM5α and the retroviral capsid

Abstract:

HIV-2 is thought to have entered the human population in the 1930s through cross-species transmission of SIV from sooty mangabeys in West Africa. Unlike HIV-1, HIV-2 has not led to a global pandemic, and recent data suggest that HIV-2 prevalence is declining in some West African states where it was formerly endemic. Although many early isolates of HIV-2 were derived from patients presenting with AIDS-defining illnesses, it was noted that a much larger proportion of HIV-2-infected subjects beh...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1111/cei.13280

Authors


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Role:
Author
ORCID:
0000-0003-2152-1617
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Subgroup:
Target Discovery Institute
Oxford college:
St Cross College
Role:
Author
ORCID:
0000-0001-5788-6998
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Publisher:
Wiley Publisher's website
Journal:
Clinical and Experimental Immunology Journal website
Volume:
196
Issue:
3
Pages:
305-317
Publication date:
2019-03-21
Acceptance date:
2019-02-07
DOI:
EISSN:
1365-2249
ISSN:
0009-9104
Pmid:
30773620
Pubs id:
pubs:975952
UUID:
uuid:40156838-1d5a-44db-a1c1-a915fdcd0a7d
Source identifiers:
975952
Local pid:
pubs:975952
Language:
English
Keywords:

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