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Delayed disease progression in HIV-2: the importance of TRIM5α and the retroviral capsid

Abstract:

HIV-2 is thought to have entered the human population in the 1930s through cross-species transmission of SIV from sooty mangabeys in West Africa. Unlike HIV-1, HIV-2 has not led to a global pandemic, and recent data suggest that HIV-2 prevalence is declining in some West African states where it was formerly endemic. Although many early isolates of HIV-2 were derived from patients presenting with AIDS-defining illnesses, it was noted that a much larger proportion of HIV-2-infected subjects beh...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1111/cei.13280

Authors


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Role:
Author
ORCID:
0000-0003-2152-1617
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Target Discovery Institute
Oxford college:
St Cross College
Role:
Author
ORCID:
0000-0001-5788-6998
Norges Forskningsråd More from this funder
Centre for AIDS research, University of Kumamoto More from this funder
British HIV Association More from this funder
Commonwealth Scholarship More from this funder
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Publisher:
Wiley Publisher's website
Journal:
Clinical and Experimental Immunology Journal website
Volume:
196
Issue:
3
Pages:
305-317
Publication date:
2019-03-21
Acceptance date:
2019-02-07
DOI:
EISSN:
1365-2249
ISSN:
0009-9104
Pmid:
30773620
Source identifiers:
975952
Language:
English
Keywords:
Pubs id:
pubs:975952
UUID:
uuid:40156838-1d5a-44db-a1c1-a915fdcd0a7d
Local pid:
pubs:975952
Deposit date:
2019-11-29

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