Targeting of T lymphocytes to melanoma cells through chimeric anti-GD3 immunoglobulin T-cell receptors.

Journal article

Immunoglobulin T-cell receptors (IgTCRs) combine the specificity of antibodies with the potency of cellular killing by grafting antibody recognition domains onto TCR signaling chains. IgTCR-modified T cells are thus redirected to kill tumor cells based on their expression of intact antigen on cell surfaces, bypassing the normal mechanism of activation through TCR-peptide-major histocompatibility complex (MHC) recognition. Melanoma is one of the most immunoresponsive of human cancers and has s...

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Authors: Yun, C; Nolan, K; Beecham, E; Reisfeld, R; Junghans, R

• Publication status: Published
• Journal: Neoplasia (New York, N.Y.)
• Volume: 2
• Issue: 5
• Pages: 449-459
• Publication date: 2000-01-01
• DOI: 10.1038/sj.neo.7900108
• EISSN: 1476-5586
• ISSN: 1522-8002
• Language: English
• Keywords: Gangliosides; Jurkat Cells; Humans; Membrane Proteins; Cytotoxicity, Immunologic; Antibodies, Monoclonal; Mice; Binding Sites; Animals; Immunoglobulin Fragments; Kidney; Immunotherapy, Adoptive; Melanoma; Genes, Immunoglobulin; Immunoglobulin Variable Region; Chemotaxis, Leukocyte; Antigens, Neoplasm; Immunoglobulin Fab Fragments; Transfection; T-Lymphocytes, Cytotoxic; Cell Line; Interleukin-2; Recombinant Fusion Proteins; Receptors, Antigen, T-Cell; Rats