Journal article icon

Journal article

Controlling the substrate selectivity of deacetoxycephalosporin/deacetylcephalosporin C synthase.

Abstract:

Deacetoxycephalosporin/deacetylcephalosporin C synthase (DAOC/DACS) is an iron(II) and 2-oxoglutarate-dependent oxygenase involved in the biosynthesis of cephalosporin C in Cephalosporium acremonium. It catalyzes two oxidative reactions, oxidative ring-expansion of penicillin N to deacetoxycephalosporin C, and hydroxylation of the latter to give deacetylcephalosporin C. The enzyme is closely related to deacetoxycephalosporin C synthase (DAOCS) and DACS from Streptomyces clavuligerus, which se...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1074/jbc.m313928200

Authors


Expand authors...
Journal:
The Journal of biological chemistry
Volume:
279
Issue:
15
Pages:
15420-15426
Publication date:
2004-04-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:4010a188-b8dd-4d3d-ab3b-8683684eeb4a
Source identifiers:
39057
Local pid:
pubs:39057

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP