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Journal article

Modification of K-ATP channels in pancreatic beta-cells by trypsin.

Abstract:

The inside-out configuration of the patch-clamp method was used to study the effects of trypsin on the activity of ATP-sensitive potassium (K-ATP) channels from isolated mouse pancreatic beta-cells. Trypsin (20 micrograms/ml) irreversibly enhanced channel activity around twofold by reducing the interburst intervals without altering the burst kinetics. No effect on the single channel conductance or the inward rectification produced by internal Mg2+ was observed: however, the protease did reduc...

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Publication status:
Published

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Publisher copy:
10.1007/bf00375103

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Pflugers Archiv : European journal of physiology
Volume:
424
Issue:
1
Pages:
63-72
Publication date:
1993-06-01
DOI:
EISSN:
1432-2013
ISSN:
0031-6768
Source identifiers:
113525
Language:
English
Keywords:
Pubs id:
pubs:113525
UUID:
uuid:40024a14-51f7-45af-a5d5-0b9eea07b13a
Local pid:
pubs:113525
Deposit date:
2012-12-19

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