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Journal article

Rapid diastereocontrolled synthesis of 2,2,5-trisubstituted pyrrolidines.

Abstract:
2,2,5-Trisubstituted pyrrolidines are available from allylic pyroglutamates by Ireland-Claisen ester rearrangement followed by Eschenmoser sulfide contraction and reduction in a highly diastereoselective and efficient sequence. Some of the products from this sequence exhibit activity against S. aureus, but are much less active against E. coli.
Publication status:
Published

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Publisher copy:
10.1039/b811642c

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Journal:
Organic and biomolecular chemistry More from this journal
Volume:
6
Issue:
20
Pages:
3664-3666
Publication date:
2008-10-01
DOI:
EISSN:
1477-0539
ISSN:
1477-0520
Language:
English
Pubs id:
pubs:34413
UUID:
uuid:400156be-66b0-41f6-bab0-26a92d430ba5
Local pid:
pubs:34413
Source identifiers:
34413
Deposit date:
2012-12-19

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