Journal article
Cross-reactive memory T cells associate with protection against SARS-CoV-2 infection in COVID-19 contacts
- Abstract:
-
Cross-reactive immune responses to SARS-CoV-2 have been observed in pre-pandemic cohorts and proposed to contribute to host protection. Here we assess 52 COVID-19 household contacts to capture immune responses at the earliest timepoints after SARS-CoV-2 exposure. Using a dual cytokine FLISpot assay on peripheral blood mononuclear cells, we enumerate the frequency of T cells specific for spike, nucleocapsid, membrane, envelope and ORF1 SARS-CoV-2 epitopes that cross-react with human endemic co...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
DH | National Institute for Health Research (NIHR)
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Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Nature Communications Journal website
- Volume:
- 13
- Issue:
- 1
- Article number:
- 80
- Place of publication:
- England
- Publication date:
- 2022-01-10
- Acceptance date:
- 2021-12-01
- DOI:
- EISSN:
-
2041-1723
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1233139
- Local pid:
- pubs:1233139
- Deposit date:
- 2022-01-21
Terms of use
- Copyright holder:
- Kundu et al.
- Copyright date:
- 2022
- Rights statement:
- © The Author(s) 2021. Open Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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