Stereochemical aspects of the interaction between isomerases and their substrates
The work presented in this thesis is concerned with the mechanism of two enzymes of the glycolytic pathway, each of which catalyzes an aldose-ketose isomerization.
The first part of the thesis deals with triosephosphate isomerase, which catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate. A mechanism has been proposed for this reaction that involves the transfer of a proton between carbon centres of the substrates, and an enzyme-boun...Expand abstract
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- University of Oxford
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- Copyright holder:
- Webb, Martin R.
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- This thesis was digitised thanks to the generosity of Dr Leonard Polonsky
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