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Thesis

Stereochemical aspects of the interaction between isomerases and their substrates

Abstract:

The work presented in this thesis is concerned with the mechanism of two enzymes of the glycolytic pathway, each of which catalyzes an aldose-ketose isomerization.

The first part of the thesis deals with triosephosphate isomerase, which catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate. A mechanism has been proposed for this reaction that involves the transfer of a proton between carbon centres of the substrates, and an enzyme-boun...

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Publication date:
1976
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Source identifiers:
601870746
Language:
English
UUID:
uuid:3ff91fc2-988b-43d7-95a1-d5a685e0e002
Local pid:
td:601870746
Deposit date:
2015-03-26

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