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Thesis

Activation of CD161-expressing T cells in human blood and gut

Abstract:

Human mucosal associated invariant T (MAIT) cells are an important T cell population present in circulation as well as immune privileged sites such as the liver and the gut. They are characterised by a semi-invariant T cell receptor (TCR) and high surface expression levels of CD161 and IL-18Rα, and restriction by the MHC class I-related protein (MR1). Studies have described a broad range of MAIT cell effector functions, including MR1-mediated antibacterial responses and TCR- independent, c...

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Department:
Nuffield Department of Medicine, University of Oxford

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Role:
Supervisor
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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