Investing the role of FGF signaling in left-right determination

Thesis

Left-right patterning is set up early in development, at embryonic day 8.5 in the mouse. Cilia are present on the cells of a transient structure, termed the node, the location where L/R symmetry is broken. In this pit-like structure, motile cilia generate a leftwards flow of extracellular fluid, which is translated into a left-specific signal by immotile cilia on crown cells at the edge of the node. How exactly this flow is translated remains unknown, with one hypothesis proposing that nod...

Expand abstract

Authors: Little, RB

• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: development; asymmetry; mouse; patterning; FGF; embryo; cilia
• Subjects: Genetics