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L3T4 and Lyt-2 T cells are both involved in the generation of low-dose streptozotocin-induced diabetes in mice.

Abstract:

In order to determine the role of different T lymphocyte subsets in the pathogenesis of low-dose streptozotocin (LD-Sz) induced diabetes, we treated mice with Sz together with repeated injections of rat monoclonal antibodies (MoAb) with specificity towards the mouse T cell differentiation markers L3T4 ('helper/inducer' T cells and some macrophages), Lyt-2 ('cytotoxic/suppressor' T cells and NK cells) and Thy-1 (pan T lymphocytes). Treatment depleted target cells in peripheral blood and spleen...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Clinical and experimental immunology
Volume:
70
Issue:
3
Pages:
585-592
Publication date:
1987-12-05
EISSN:
1365-2249
ISSN:
0009-9104
URN:
uuid:3fea2272-4387-4cc2-b8c2-1c0596f4554c
Source identifiers:
1949
Local pid:
pubs:1949

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