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From genes to function: the next challenge to understanding multiple sclerosis

Abstract:

Susceptibility to multiple sclerosis is jointly determined by genetic and environmental factors, and progress has been made in defining some of these genetic associations, as well as their possible interactions with the environment. However, definitive proof for the involvement of specific genetic determinants in the disease will only come from studies that examine their functional roles is disease pathogenesis. New and combined approaches are needed to analyse the complexity of gene regulati...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/nri2554

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Institution:
Aarhus University Hospital, Aarhus, Denmark
Department:
Clinical Institute
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Institution:
Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany
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Institution:
University of Oxford
Research group:
MRC Human Immunology Unit
Department:
Medical Sciences Division - Molecular Medicine,Weatherall Institute of
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Funding agency for:
Manuel A. Friese
Danish Medical Research Council More from this funder
Medical Research Council More from this funder
Karen Elise Jensen Foundation More from this funder
Lundbeck Foundation More from this funder
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Publisher:
Macmillan Publishers Ltd Publisher's website
Journal:
Nature Reviews Immunology Journal website
Volume:
9
Pages:
408-417
Publication date:
2009-06-05
DOI:
EISSN:
1474-1741
ISSN:
1474-1733
URN:
uuid:3fe2cc7b-66c8-418c-ad91-6342ec71167e
Local pid:
ora:5271
Language:
English
Subjects:

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