Gradient collagen/nanohydroxyapatite composite scaffold: development and characterization.

Journal article

This paper reports an in situ diffusion method for the fabrication of compositionally graded collagen/nanohydroxyapatite (HA) composite scaffold. The method is diffusion based and causes the precipitation of nano-HA crystallites in situ. A collagen matrix acts as a template through which calcium ions (Ca(2+)) and phosphate ions (PO4(3-)) diffuse and precipitate a non-stoichiometric HA. It was observed that needle-like prismatic nano-HA crystallites (about 2 x 2 x 20 nm) precipitated in the in...

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Authors: Liu, C; Han, Z; Czernuszka, J

• Publication status: Published
• Journal: Acta biomaterialia
• Volume: 5
• Issue: 2
• Pages: 661-669
• Publication date: 2009-02-01
• DOI: 10.1016/j.actbio.2008.09.022
• EISSN: 1878-7568
• ISSN: 1742-7061
• Language: English
• Keywords: Tomography, X-Ray Computed; Spectrum Analysis; Microscopy, Electron, Transmission; Nanoparticles; Cattle; Durapatite; Collagen; X-Rays; Hydrogen-Ion Concentration; Animals