Journal article
Discovery of active mouse, plant and fungal cytochrome P450s in endogenous proteomes and upon expression in planta
- Abstract:
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Eukaryotes produce a large number of cytochrome P450s that mediate the synthesis and degradation of diverse endogenous and exogenous metabolites. Yet, most of these P450s are uncharacterized and global tools to study these challenging, membrane-resident enzymes remain to be exploited. Here, we applied activity profiling of plant, mouse and fungal P450s with chemical probes that become reactive when oxidized by P450 enzymes. Identification by mass spectrometry revealed labeling of a wide range...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 2.3MB, Terms of use)
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(Preview, Version of record, pdf, 734.1KB, Terms of use)
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- Publisher copy:
- 10.1038/s41598-024-60333-x
Authors
Funding
+ Biotechnology and Biological Sciences Research Council
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Funder identifier:
https://ror.org/00cwqg982
Bibliographic Details
- Publisher:
- Nature Research
- Journal:
- Scientific Reports More from this journal
- Volume:
- 14
- Issue:
- 1
- Article number:
- 10091
- Publication date:
- 2024-05-02
- Acceptance date:
- 2024-04-22
- DOI:
- EISSN:
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2045-2322
Item Description
- Language:
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English
- Keywords:
- Source identifiers:
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1938978
- Deposit date:
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2024-07-20
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