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Toll-like receptor activation during cutaneous allergen sensitization blocks development of asthma through IFN-gamma-dependent mechanisms

Abstract:: Toll-like receptors (TLRs) are pattern-recognition receptors that have a pivotal role as primary sensors of microbial products and as initiators of innate and adaptive immune responses. We investigated the role of TLR2, TLR3, and TLR4 activation during cutaneous allergen sensitization in the modulation of allergic asthma. The results show that dermal exposure to TLR4 ligand lipopolysaccharide (LPS) or TLR2 ligand Pam 3 Cys suppresses asthmatic responses by reducing airway hyperreactivity, muc...
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APA Style

Haapakoski, R., Karisola, P., Fyhrquist, N., Savinko, T., Lehtimäki, S., Wolff, H., Lauerma, A., & Alenius, H. (2013). Toll-like receptor activation during cutaneous allergen sensitization blocks development of asthma through IFN-gamma-dependent mechanisms. Journal of Investigative Dermatology, 133(4), 964–972.

MLA Style

Haapakoski, R., et al. “Toll-like Receptor Activation during Cutaneous Allergen Sensitization Blocks Development of Asthma through IFN-Gamma-Dependent Mechanisms.” Journal of Investigative Dermatology, vol. 133, no. 4, 2013, pp. 964–72.

Chicago Style

Haapakoski, R, P Karisola, N Fyhrquist, T Savinko, S Lehtimäki, H Wolff, A Lauerma, and H Alenius. 2013. “Toll-like Receptor Activation during Cutaneous Allergen Sensitization Blocks Development of Asthma through IFN-Gamma-Dependent Mechanisms.” Journal of Investigative Dermatology 133 (4): 964–72.
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Publisher copy:: 10.1038/jid.2012.356

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+ Haapakoski, R More by this author

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+ Karisola, P More by this author

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+ Fyhrquist, N More by this author

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+ Savinko, T More by this author

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+ Lehtimäki, S More by this author

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Bibliographic Details

Journal:: Journal of Investigative Dermatology
Volume:: 133
Issue:: 4
Pages:: 964-972
Publication date:: 2013-04-01
DOI:: 10.1038/jid.2012.356
EISSN:: 1523-1747
ISSN:: 0022-202X

Item Description

Language:: English
Pubs id:: pubs:394565
UUID:: uuid:3fd735a2-c4b0-4413-912c-c1761803070a
Local pid:: pubs:394565
Source identifiers:: 394565
Deposit date:: 2013-11-16

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Copyright date:: 2013

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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