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Fine-mapping of the spinal muscular atrophy locus to a region flanked by MAP1B and D5S6.

Abstract:

The microtubule-associated protein 1B (MAP1B) locus has been mapped in close proximity to spinal muscular atrophy (SMA) on chromosome 5q13. We have identified a second microsatellite within a MAP1B intron, which increases the heterozygosity of this locus to 94%. Two unambiguous recombination events establish MAP1B as a closely linked, distal flanking marker for the disease locus, while a third recombinant establishes D5S6 as the proximal flanking marker. The combination of key recombinants an...

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Publication status:
Published

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Authors


Brzustowicz, LM More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
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Journal:
Genomics
Volume:
13
Issue:
4
Pages:
991-998
Publication date:
1992-08-05
DOI:
EISSN:
1089-8646
ISSN:
0888-7543
URN:
uuid:3fca553e-5701-4244-bfd6-4d5766d653a9
Source identifiers:
43870
Local pid:
pubs:43870

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