Journal article
High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors.
- Abstract:
-
Selective protein kinase inhibitors have only been developed against a small number of kinase targets. Here we demonstrate that "high-throughput kinase profiling" is an efficient method for the discovery of lead compounds for established as well as unexplored kinase targets. We screened a library of 118 compounds constituting two distinct scaffolds (furan-thiazolidinediones and pyrimido-diazepines) against a panel of 353 kinases. A distinct kinase selectivity profile was observed for each sca...
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- Publication status:
- Published
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- Publisher copy:
- 10.1016/j.chembiol.2011.05.010
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Authors
Bibliographic Details
- Journal:
- Chemistry and biology
- Volume:
- 18
- Issue:
- 7
- Pages:
- 868-879
- Publication date:
- 2011-07-05
- DOI:
- EISSN:
-
1879-1301
- ISSN:
-
1074-5521
- URN:
-
uuid:3fc76a1d-c758-445c-966d-877a240e3f12
- Source identifiers:
-
172273
- Local pid:
- pubs:172273
Item Description
- Language:
- English
- Keywords:
Terms of use
- Copyright date:
- 2011
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