High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors.

Miduturu, CV; Deng, X; Kwiatkowski, N; Yang, W; Brault, L; Filippakopoulos, P; Chung, E; Yang, Q; Schwaller, J; Knapp, S; King, RW; Lee, JD; Herrgard, S; Zarrinkar, P; Gray, NS

Abstract:

Selective protein kinase inhibitors have only been developed against a small number of kinase targets. Here we demonstrate that "high-throughput kinase profiling" is an efficient method for the discovery of lead compounds for established as well as unexplored kinase targets. We screened a library of 118 compounds constituting two distinct scaffolds (furan-thiazolidinediones and pyrimido-diazepines) against a panel of 353 kinases. A distinct kinase selectivity profile was observed for each sca...

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APA Style

Miduturu, C. V., Deng, X., Kwiatkowski, N., Yang, W., Brault, L., Filippakopoulos, P., Chung, E., Yang, Q., Schwaller, J., Knapp, S., King, R. W., Lee, J. D., Herrgard, S., Zarrinkar, P., & Gray, N. S. (2011). High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors. Chemistry and Biology, 18(7), 868–879.

MLA Style

Miduturu, C. V., et al. “High-Throughput Kinase Profiling: a More Efficient Approach toward the Discovery of New Kinase Inhibitors.” Chemistry and Biology, vol. 18, no. 7, Chemistry and biology, 2011, pp. 868–79.

Chicago Style

Miduturu, CV, X Deng, N Kwiatkowski, W Yang, L Brault, P Filippakopoulos, E Chung, et al. 2011. “High-Throughput Kinase Profiling: a More Efficient Approach toward the Discovery of New Kinase Inhibitors.” Chemistry and Biology 18 (7): 868–79.
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