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High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors.

Abstract:

Selective protein kinase inhibitors have only been developed against a small number of kinase targets. Here we demonstrate that "high-throughput kinase profiling" is an efficient method for the discovery of lead compounds for established as well as unexplored kinase targets. We screened a library of 118 compounds constituting two distinct scaffolds (furan-thiazolidinediones and pyrimido-diazepines) against a panel of 353 kinases. A distinct kinase selectivity profile was observed for each sca...

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Publication status:
Published

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Journal:
Chemistry and biology
Volume:
18
Issue:
7
Pages:
868-879
Publication date:
2011-07-01
DOI:
EISSN:
1879-1301
ISSN:
1074-5521
Source identifiers:
172273

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