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Thesis

Peptidoglycan recycling in the Gram-positive bacterium Staphylococcus aureus and its role in host-pathogen interaction

Subtitle:
Aminosugar recycling in S. aureus may be linked to virulence
Abstract:

Bacteria are enclosed by a peptidoglycan sacculus, an exoskeleton-like polymer composed of glycan strands cross-linked by short peptides. The sacculus surrounds the cell in a closed bag-like structure and forms the main structural component of the bacterial cell wall. As bacteria grow and divide, cell wall remodelling by peptidoglycan hydrolases results in the release of peptidoglycan fragments from the sacculus. In Gram-negative bacteria, these fragments are efficiently trapped and recycl...

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Department:
New Biochemistry, Department of Biochemistry, University of Oxford
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Funding agency for:
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Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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