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A common LPA null allele associates with lower lipoprotein(a) levels and coronary artery disease risk

Abstract:

OBJECTIVE - Increased levels of lipoprotein(a) are a highly heritable risk factor for coronary artery disease (CAD). The genetic determinants of lipoprotein(a) levels are mainly because of genetic variation in the apolipoprotein(a) gene (LPA). We have tested the association of a relatively common null allele of LPA with lipoprotein(a) levels and CAD risk in a large case-control cohort. We have also examined how null allele genotyping complements apolipoprotein(a) isoform typing to refine the ...

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Publisher copy:
10.1161/ATVBAHA.114.303462

Authors


Kyriakou, T More by this author
Seedorf, U More by this author
Hopewell, JC More by this author
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Publisher:
Lippincott Williams and Wilkins
Journal:
Arteriosclerosis, Thrombosis, and Vascular Biology
Volume:
34
Issue:
9
Pages:
2095-2099
Publication date:
2014
DOI:
EISSN:
1524-4636
ISSN:
1079-5642
URN:
uuid:3fc1fb4c-fe67-404e-a184-39b0a7689b6d
Source identifiers:
484747
Local pid:
pubs:484747
Language:
English
Keywords:

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