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Journal article

T cell receptor and coreceptor CD8 alphaalpha bind peptide-MHC independently and with distinct kinetics.

Abstract:

The T cell surface glycoprotein CD8 enhances T cell antigen recognition by binding to MHC class I molecules. We show that human CD8 alphaalpha binds to the MHC class I molecule HLA-A2 with an extremely low affinity (Kd approximately 0.2 mM at 37 degrees C) and with kinetics that are between 2 and 3 orders of magnitude faster than reported for T cell receptor/peptide-MHC interactions. Furthermore, CD8 alphaalpha had no detectable effect on a T cell receptor (TCR) binding to the same peptide-MH...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
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Journal:
Immunity
Volume:
10
Issue:
2
Pages:
219-225
Publication date:
1999-02-01
DOI:
EISSN:
1097-4180
ISSN:
1074-7613
Source identifiers:
9732
Language:
English
Keywords:
Pubs id:
pubs:9732
UUID:
uuid:3fbd711a-c6e3-4793-a834-9d312150711d
Local pid:
pubs:9732
Deposit date:
2012-12-19

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