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Thesis

Copper-mediated nucleophilic 18F-radiolabelling of (hetero)arenes for applications in positron emission tomography

Abstract:

This thesis focuses on the development of a novel nucleophilic 18F-fluorination of (hetero)arenes and of a rapid screening experiment to facilitate the application of this reaction to complex heterocyclic targets of medicinal importance.

Chapter 1 introduces the use of molecules labelled with fluorine-18 as tracers in positron emission tomography and reviews methods for the preparation of [18F]fluoroarenes published prior to the start of the wo...

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Supervisor
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Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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