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Simian Virus 40 depends on ER protein folding and quality control factors for entry into host cells.

Abstract:

Cell entry of Simian Virus 40 (SV40) involves caveolar/lipid raft-mediated endocytosis, vesicular transport to the endoplasmic reticulum (ER), translocation into the cytosol, and import into the nucleus. We analyzed the effects of ER-associated processes and factors on infection and on isolated viruses and found that SV40 makes use of the thiol-disulfide oxidoreductases, ERp57 and PDI, as well as the retrotranslocation proteins Derlin-1 and Sel1L. ERp57 isomerizes specific interchain disulfid...

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Publication status:
Published

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Publisher copy:
10.1016/j.cell.2007.09.038

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Journal:
Cell
Volume:
131
Issue:
3
Pages:
516-529
Publication date:
2007-11-01
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
Source identifiers:
95890

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